Sclerostin's role in bone's adaptive response to mechanical loading
نویسندگان
چکیده
منابع مشابه
Sclerostin's role in bone's adaptive response to mechanical loading
Mechanical loading is the primary functional determinant of bone mass and architecture, and osteocytes play a key role in translating mechanical signals into (re)modelling responses. Although the precise mechanisms remain unclear, Wnt signalling pathway components, and the anti-osteogenic canonical Wnt inhibitor Sost/sclerostin in particular, play an important role in regulating bone's adaptive...
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OBJECTIVE Short-term neurectomy-induced disuse (SN) has been shown to restore load responses in aged mice. We examined whether this restoration was further enhanced in both cortical and trabecular bone by simply extending the SN. METHODS Following load:strain calibration, tibiae in female C57BL/J6 mice at 8, 14 and 20 weeks and 18 months (n=8/group) were loaded and bone changes measured. Effe...
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........................................................................................... 7 Populärvetenskaplig sammanfattning ............................................. 9 List of papers .................................................................................. 11 Abbrevations .................................................................................. 13 Introduction ..........
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Tendinopathies are commonly attributable to accumulation of sub-rupture fatigue damage from repetitive use. Data is limited to late stage disease from patients undergoing surgery, motivating development of animal models, such as ones utilizing treadmill running or repetitive reaching, to investigate the progression of tendinopathies. We developed an in vivo model using the rat patellar tendon t...
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ژورنال
عنوان ژورنال: Bone
سال: 2017
ISSN: 8756-3282
DOI: 10.1016/j.bone.2016.10.008